郝爱军，毕业于山东医科大学，山东大学医学院组织学与胚胎学教研室教授，博士生导师。

郝爱军，毕业于山东医科大学，获医学学士，医学硕士学位；1993年至1999年在山东医科大学医学系组织学与胚胎学教研室任教。后赴新加坡国立大学攻读博士学位，2002年毕业于新加坡国立大学医学院神经科学专业，获博士学位。同年进入新加坡国立分子生物学研究所做高级研究员。2004年作为高层次引进人才回山东大学医学院组织学与胚胎学教研室担任教授, 博士生导师。

1999/5 - 2002/5，新加坡国立大学，医学院分子神经发育生物学实验室，博士，导师：Ling Eng-ang

1990/9 - 1993/7，山东医科大学，组织胚胎学教研室，硕士，导师：高英茂

1985/9 - 1990/7，山东医科大学，医学院，学士

2004/5 - 至今，山东大学，医学院组胚，教授

2002/07-2004/04，新加坡国立分子生物学研究院,细胞信号传导实验室, Research Fellow

1999/07-2002/06，新加坡国立大学,医学院分子神经发育生物学实验室，Teaching Assistant

1993/06-1999/06，山东医科大学，组织胚胎学教研室，助教，讲师

在我国著名胚胎学家高英茂教授指导下，从事生长因子在胚胎细胞分化过程中作用的研究, 对与胚胎细胞分化发育密切相关的多种蛋白进行了系统的免疫组化和分子原位杂交研究。后在著名神经科学学家、新加坡科学院院士Eng Ang Ling （小胶质细胞的发现者）教授的指导下，从事胶质细胞的起源、功能和各种病理状态下胶质细胞作用机制的研究。对于传统的神经病理和神经发育生物学研究打下了深厚的理论和实验基础，建立了理想的动物模型，并在体外神经细胞的培养方面对胶质细胞的功能机制进行了深入的研究。期间还在神经发育生物学家S.T. Dheen的分子神经生物学实验室，利用RT-PCR、microarray differential display等方法对神经发育疾病发生机制进行了更加深入的探索。应著名生物化学和分子生物学家、细胞信号传导分子STAT3的主要研究者、新加坡科学技术委员会（A*STAR）首席科学家Xinmin Cao教授的邀请，进入到新加坡国立分子生物学研究所做高级研究员，并与之进行了合作研究。充分利用分子生物学和生物化学的高技术方法，如：分子克隆（Cloning）、基因剔除（Gene knock-out）、细胞转染（Cell Transfection）、蛋白质分析技术等进一步做关于神经发育机制和功能方面的研究。主要以神经干细胞和胚胎干细胞的诱导分化, 信号传导以及它们在临床疾病模型的应用研究作为自己的主要研究方向。

美国神经科学协会会员(The American Society for Neuroscience)；新加坡神经科学协会会员(Neuroscience Society of Singapore)；新加坡显微技术协会会员(Microscopy Society of Singapore)。

中华医学会细胞生物学会理事，山东省解剖学会副理事长，美国细胞生物学协会会员（The American Society for Cell Biology）。

教育部2004年度“新世纪优秀人才支持计划”；山东省卫生系统第二批杰出学科带头人和中青年重点科技人才；山东省科学技术厅2004山东省优秀中青年科学家科研奖励。

2011年2月10日政协省十届十六次常委会议审议通过，增补为十届山东省政协委员。

1. 国家自然科学基金，81771219，TOX3在原发性小头畸形发生中的作用及机制研究，2018/1-2021/12，54万，在研，主持

2. 山东省重点研发计划, 2018GSF118076, TOX3在大脑皮层发育缺陷中的作用机制研究及对认知功能障碍的影响，2018/1-2019/12, 15 万，在研，主持

3. 国家自然科学基金，81571093，Sox19b在神经管发育缺陷中的新作用及机制研究，2016/1-2019/12，57万，在研，主持

4. 国家自然科学基金（应急管理项目），31440056，小分子化合物对胚胎神经干细胞作用的新发现及机制研究，2015/1-2015/12，15万，已结题，主持

5. 国家自然科学基金（面上项目），31271289，DHHC16对胚胎端脑NSCs调控作用的研究， 2013/1-2016/12，80万，已结题，主持

6. 国家自然科学基金（面上项目），81071057，G-CSF 对脑瘫内源性NSCs的作用及作用机制研究，2011/1-2013/12，36 万，已结题，主持

7. 国家自然科学基金（面上项目）, 30771142, 蛋白H 在神经发育中作用的研究, 2008/1-2010/12，27 万，已结题，主持

8. 山东省杰出青年基金，JQ200823，Oct4 在NSCs正常及异常发生中的作用及其机制的研究，2008-2011，50 万，已结题，主持

9. 国家自然科学基金（面上项目）, 30671105, 妊娠糖尿病致神经管畸形发生机理的研究, 2007/1-2009/12，30 万，已结题，主持

10. 山东省自然科学基金重点项目, Z2007C11, 蛋白H在神经元蛋白棕榈酰化中作用的研究，2007/12-2010/12, 10 万，已结题，主持

11. 新世纪优秀人才支持计划，2004年

12. 曾获国际脑科学研究组织(The international Brain Research Organization),国际发育神经生物学学会(The International Society For Developmental)，欧洲健康和疾病研究会(European Society for cell Function in Health)和新加坡李氏基金(Lee Foundation, Singapore)的资助和奖励。曾主持新加坡国立大学的重要科研项目Molecular and morphological analysis of Neural Tube Defects in Embryos of Diabetic and Retinoic Acid Treated Rats(R-181-000-027-112) 和新加坡医学研究委员会重要科研项目Analysis of Regulatory Factor Involved in Neurdoxicing in Neurodegeneratine Disease(R-181-000-058-213) 。

1. Li, Xian, Chen, Xueran, Zhou, Wenjuan, Ji, Shufang, Li,Xinyue, Li,Guanchong, Liu, Guowei, Wang, Fuwu, Hao, Aijun(*), Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14. Neuroscience. 2017 Aug 4. pii: S0306-4522(17)30550-X.

2. Chen, Xueran, Du, Zhaoxia, Li, Xian, Wang, Liyan, Wang, Fuwu, Shi, Wei, Hao, Aijun(*), Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity. Molecular Neurobiology. 2016.10.01，53（8）：5722~5736

3. Shi Wei，Chen Xueran，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Hao Aijun(*), ZDHHC16 Modulates FGF/ERK Dependent Proliferation of Neural Stem/Progenitor Cells in the Zebrafish Telencephalo, Developmental Neurobiology，2016.9.3，76（9）：1014~1028

4. Du, Zhaoxia, Chen, Xueran(*), Li, Xian, He, Kun, Ji, Shufang, Shi,Wei, Hao, Aijun(*)，Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Biochemical and Biophysical Research Communications，2016.6.24，475：194~201

5. Guo Yuji, Liu Shangming, Zhang Xianghong, Wang Liyan, Gao Jiangang, Han Aiqing(*), Hao Aijun (*), G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice. Laboratory Investigation，2015.12.1，95：1439~1449

6. Wang Fen，Chen Xueran，Shi Wei，Yao Linli，Gao Ming，Yang Yang，Hao Aijun(*)，Zdhhc15b Regulates Differentiation of Diencephalic Dopaminergic Neurons in Zebrafish. Journal of Cellular Biochemistry，2015.12.01，116：2980~2991

7. Liu, Shangming，Guo, Yuji，Yuan, Qiuhuan，Pan, Yan，Wang, Liyan，Liu, Qian，Wang, Fuwu，Wang, Jingjing(*) , Hao, Aijun(*)， Melatonin prevents neural tube defects in the offspring of diabetic pregnancy. Journal of Pineal Research，2015.11.01，59：508~517

8. Shi Wei，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Chen Xueran(*)，Hao Aijun(*)， ZDHHC17 promotes axon outgrowth by regulating TrkA–tubulin complex formation，Molecular and Cellular Neuroscience，2015.9.01，68：194~202

9. Chen Wang，Xueran Chen，Wei Shi，Fen Wang，Zhaoxia Du，Xian Li，Yao Yao，Tong Liu，Tong Shao，Gang Li，Hao Aijun(*)，2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Neurotoxicology and Teratology，2015.7.01，50：53~63

10. Wang, Fuwu，Zhou, Huaiyu，Du, Zhaoxia，Chen, Xueran，Zhu, Faliang，Wang, Zhen，Zhang, Yanmin，Lin, Lin，Qian, Mingyu，Zhang, Xianghong，Li, Xingang(*), Hao, Aijun(*)，Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. European Journal of Pharmacology，2015.2.5，748：157~165

11. Zhang yanmin，Ni Shilei，Huang Bin，Wang Liyan，Zhang Xianghong，Li Xian，Wang Han，Liu Shuai，Hao Aijun(*), Li Xingang(*)， Overexpression of SCLIP promotes growth and motility in glioblastoma cells. Cancer Biol Ther.，2015.1.1，16：97~105

12. Chen X, Shi W, Wang F, Du Z, Yang Y, Gao M, Yao Y, He K, Wang C, Hao A*. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Stem Cells Dev, 2014, 23(16):1899-1909.

13.Chen X, Du Z, Shi W, Wang C1, Yang Y, Wang F, Yao Y, He K, Hao A*. 2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation. Stem Cell Res, 2014, 12(2):481–491.

14. Chen X, Li X, Du Z, Shi W, Yao Y, Wang C, He K, Hao A*. Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation. Journal of Pineal Research, 2014, 57(2):168–176

15. Liu, D., Wang, Z., Zhan, J., Zhang, Q., Wang, J., Xian, X., Luan, Q., and Hao, A*. Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis. Pharmacol Biochem Behav ,2014,116, 55-63.

16. Wang, Z., Liu, D., Zhang, Q., Wang, J., Zhan, J., Xian, X., Du, Z., Wang, X., and Hao, A*.Palmitic acid affects proliferation and differentiation of neural stem cells in vitro. J Neurosci Res, 2014.

17. Zhang Y, Liu Q, Wang F, Ling EA, Liu S, Wang L, Yang Y, Yao L, Chen X, Wang F, Shi W, Gao M, Hao A*. Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α. J Pineal Res. 2013 Sep;55 (2):121-30. doi: 10.1111/jpi.12052. Epub 2013 Mar 29.

18. Li, L., Wang, J., Chau, J.F., Liu, H., Li, B., Hao, A., and Li, J*. Smad1 stabilization and delocalization in response to the blockade of BMP activity. Cell Mol Biol Lett,2013 ,18, 340-354.

19. Liu, Q., Wang, L., Wang, Z., Yang, Y., Tian, J., Liu, G., Guan, D., Cao, X., Zhang, Y*., and Hao, A. GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1alpha destabilization. Carcinogenesis, 2013, 34, 1728-1736.

20. Wang, L., Liu, Q., Zhao, H., Cui, K*., Yao, L., Nie, F., Jin, G., Hao, A*., and Wong, S.T.. Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion. J Neurosci Res ,2013a, 91, 128-137.

21. Wang, Z., Liu, D., Zhan, J., Xie, K., Wang, X., Xian, X., Gu, J., Chen, W., and Hao, A*. Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice. Pharmacol Res ,2013b, 76, 84-97.

22. Yao, L., Cao, Q., Wu, C., Kaur, C., Hao, A., and Ling, E.A*. Notch signaling in the central nervous system with special reference to its expression in microglia. CNS Neurol Disord Drug Targets ,2013a ,12, 807-814.

23. Yao, L., Kan, E.M., Kaur, C., Dheen, S.T., Hao, A., Lu, J., and Ling, E.A*. Notch-1 Signaling Regulates Microglia Activation via NF-kappaB Pathway after Hypoxic Exposure In Vivo and In Vitro. PLoS One, 2013b, 8, e78439.

24. Yao, L., Kan, E.M., Lu, J., Hao, A., Dheen, S.T., Kaur, C*., and Ling, E.A*. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation, 2013c, 10, 23.

25. Yuan, Q., Zhao, S., Liu, S., Zhang, Y., Fu, J., Wang, F., Liu, Q., Ling, E.A., and Hao, A*. Folic acid supplementation changes the fate of neural progenitors in mouse embryos of hyperglycemic and diabetic pregnancy. J Nutr Biochem, 2013a, 24, 1202-1212.

26. Yuan, Q., Zhao, S., Wang, F., Zhang, H., Chen, Z.J., Wang, J., Wang, Z., Du, Z., Ling, E.A., Liu, Q*., Hao, A*. Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase. Stem Cell Res ,2013b, 10, 257-266.

27. Chen, Y., Lu, H., Liu, Q., Huang, G., Lim, C.P., Zhang, L., Hao, A*., and Cao, X*. Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity. J Biol Chem ,2012, 287, 27227-27235.

28. Ma, G., Li, L., Hu, Y., Chau, J.F., Au, B.J., Jia, D., Liu, H., Yeh, J., He, L., Hao, A*., and Li, B*. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol ,2012, 4, 118-120.

29. Wang, J., Hao, H., Yao, L., Zhang, X., Zhao, S., Ling, E.A., Hao, A*, and Li, G*. Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells. J Pineal Res, 2012a, 53, 180-187.

30. Wang, J., Yao, L., Zhao, S., Zhang, X., Yin, J., Zhang, Y., Chen, X., Gao, M., Ling, E.A., Hao, A*, Li, G*. Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells. Cancer Biol Ther, 2012b, 13, 389-400.

31. Wang, L., Zhao, H., Cui, K*., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., Jin, G., Liu, Q*., Wong , ST. Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening. Biosci Trends, 2012c, 6, 192-200.

32. Wang, Z., Liu, D., Wang, F., Liu, S., Zhao, S., Ling, E.A., and Hao, A*. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling. Br J Nutr, 2012d, 107, 229-241.

33. Wang, Z., Liu, D., Wang, J., Liu, S., Gao, M., Ling, E.A., and Hao, A*. Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro. J Pineal Res, 2012e, 52, 253-264.

34. Liu, D., Wang, Z., Liu, S., Wang, F., Zhao, S., and Hao, A* Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells. Neuropharmacology, 2011a, 61, 592-599.

35. Liu, S., Yuan, Q., Zhao, S., Wang, J., Guo, Y., Wang, F., Zhang, Y., Liu, Q., Zhang, S., Ling, E.A., Hao, A*. High glucose induces apoptosis in embryonic neural progenitor cells by a pathway involving protein PKCdelta. Cell Signal, 2011b, 23, 1366-1374.

36. Ren, S., Wang, X., Ma, B*., Yuan, Q., Zhang, H., Yu, X., and Hao, A. Arnebia preventing the expression of Muc1 protein decrease results in anti-implantation in early pregnant mice. Contraception, 2011, 83, 378-384.

37. Shidou Zhao（#）, Qiuhuan Yuan（#）, Hongbo Hao, Yuji Guo, Shangming Liu, Yanmin Zhang, Jianli Wang, Huijuan Liu, Fuwu Wang, Kai Liu, Eng-Ang Ling, and Aijun Hao（*）, Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma, J Pathol, 2011, 223: 672-682。

38. Yuji Guo（#）, Shangming Liu（#）, Ping Wang, Shidou Zhao, Fuwu Wang, Lujun Bing, Yanmin Zhang, Eng-Ang Ling, Jiangang Gao（*） and Aijun Hao（*）, Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas, Histopathology, 2011, 59: 763-775。

39. Yanmin Zhang（#）, Hongbo Hao（#）, Shidou Zhao, Qian Liu, Qiuhuan Yuan, Shilei Ni, Fuwu Wang, Shangming Liu, Liyan Wang, and Aijun Hao（*）, Downregulation of GRIM-19 promotes growth and migration of human glioma cells, Cancer Sci, 2011, 102: 1991-1999。

40. Fu-wu Wang（#）, Hong-bo Hao, Shi-dou Zhao, Yan-min Zhang, Qian Liu, Hui-juan Liu, Shang-ming Liu, Qiu-huan Yuan, Lu-jun Bing, Eng-Ang Ling, Ai-jun Hao, Roles of activated astrocyte in neural stem cell proliferation and differentiation, Stem Cell Res. 2011 Jul;7(1):41-53.

41. Jie Fu（#）, Shi-Dou Zhao, Hui-Juan Liu, Qiu-Huan Yuan, Shang-Ming Liu, Yan-Min Zhang, Eng-Ang Ling, Ai-Jun Hao, Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. J Pineal Res. 2011 Aug;51(1):104-12.