陈吉龙，男，汉族，1965年8月出生，福建福州人，美国侨眷，研究生学历，博士学位，致公党党员。现任福建农林大学动物科学学院院长、教授、博士生导师。

1982-1986年 福建农林大学(原福建农学院)　学士

1986-1989年 中国农业大学(原北京农业大学)　硕士

1989-1992年　北京大学　博士

1992-1993年　中国科学院遗传与发育生物学研究所（原中国科学院发育生物学研究所）　助理研究员

1993-1994年　中国科学院发育生物学研究所　副研究员(中国科学院破格提拔)

1994-1998年　美国爱荷华大学（University of Iowa）生物化学系　博士后

1998-2000年　中国科学院发育生物学研究所，副研究员、研究员、研究组负责人、青年科学家创新小组负责人

2000-2008年　美国爱荷华大学（University of Iowa）医学院访问学者 研究员

2008年-至今　中国科学院“百人计划”。中国科学院微生物研究所研究员（2017年起为兼职）、研究组负责人、博士生导师

2013年-至今 福建农林大学动物科学学院院长，教授，博士生导师，福建省“百人计划”入选者

2017年12月当选福建省侨联第十届委员会兼职副主席

2023年8月当选福建省侨联第十一届兼职副主席。

担任中国畜牧兽医学会兽医公共卫生学分会副理事长，中国免疫学会兽医免疫分会副理事长，中国畜牧兽医学会动物传染病学分会副理事长。

主要从事动物病原微生物与免疫学、病毒致癌机理等领域研究。包括以下几个研究方向：

1、流感病毒致病机理研究；

2、宿主抗病毒免疫的调控机制研究；

3、长链非编码RNA与病毒感染、肿瘤发生的关系；

4、病毒感染和癌基因诱发肿瘤发生的分子机理。

正在主持及主持过国家自然科学基金重大研究计划培育项目、重点项目、面上项目、国家“973”计划课题、国家科技重大专项课题、国家科技支撑专项课题等20多个项目。

正在主持的项目：

（1）项目名称：非细胞因子依赖性的宿主早期抗病毒免疫应答机制；经费来源：国家自然科学重点项目（联合基金项目）；

（2）项目名称：动物流感病毒与宿主RNA 互作机制研究（2021YFD1800205）；经费来源：国家重点研发计划课题；

（3）项目名称：新鉴定的lncRNAs在流感病毒与宿主互作过程中的作用及其机制；经费来源：国家自然科学基金重点项目；

（4）项目名称：STATs蛋白在宿主抗流感病毒天然免疫中的功能研究；经费来源：国家自然科学基金联合基金项目（促进海峡两岸科技合作联合基金）；

在国际上最早筛选、鉴定并命名了重要的长链非编码 RNA--lncRNA NRAV，发现NRAV在抗病毒天然免疫反应中具有重要调控功能；在国际上首次应用Knockout小鼠模型，揭示了PIM激酶家族在Abl癌基因诱发淋巴细胞癌/白血病中的关键性作用；应用Knockout小鼠模型，揭示了Abl癌蛋白持续激活JAK/STAT信号通路的分子机理；系统地研究了病原微生物入侵机体后，T细胞活化的信号转导通路。揭示了Itk/SLP76/PLC1信号通路的活化机制；系统地研究了一些小分子GTPase、分子马达蛋白在细胞内物质转运及其与细胞转化癌变关系的分子机理。揭示了Cdc42和dynein在细胞内物质转运中的关键性作用；深入地研究了细胞因子信号通路的负调控机制。阐明了细胞因子信号的抑制因子(SOCS1)的功能，并在国际上首次鉴定了SOCS1的磷酸化位点。

在国内外重要学术刊物上发表论文80余篇，授权专利4项，主编专著一本（高等教育出版社，ISBN: 7-04-005107-9），其中SCI论文60余篇，在国际核心学术刊物 Lancet、The Lancet Infectious Diseases、Cell Host & Microbe、Nucleic Acids Research、Blood、PLoS Pathogens、PNAS、Cancer Research、Oncogene、Journal of Cell Biology、Neoplasia、Journal of Virology、Journal of Biological Chemistry、Veterinary Research、Veterinary Microbiology、Molecular Cancer等杂志上发表了高水平研究论文。先后十多次应邀参加国际学术会议，多次在大会或分组会上做学术报告或主持会议，发表了30余篇国际学术会议论文摘要。

福建省侨联第十一届委员会兼职副主席

福建省自然科学奖二等奖（主持人）

第七届中国侨界贡献奖二等奖

大北农科技奖创新奖二等奖

中国科学院朱李月华优秀教师奖

中国科学院微生物研究所优秀教师奖教金

北京大学光华奖

北京农业大学（现为中国农业大学）科技进步二等奖

国家教委科技进步三等奖

《发育生物学进展》获国家教委第三届优秀教材中青年奖(第一作者)

中国科学院发育生物学研究所先进工作者

美国心脏协会研究奖(Research award)

1.ShashaLiu#, Siya Liu#, Ziding Yu#, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, JinxuanHong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang and Ji-Long Chen*. STAT3 regulates antiviral immunity by suppressingexcessive interferon signaling. Cell Reports. 2023;42(7):112806.(*为通讯作者，下同)

2. KulRaj Rai#, Yuan Liao#, Mengjuan Cai#, Haori Qiu, Faxin Wen, Min Peng, Song Wang,Shasha Liu, Guijie Guo, Xiaojuan Chi, Mohamed Maarouf, Yuhai Chen, Shile Huang and Ji-Long Chen*. MIR155HG plays abivalent role in regulating innate antiviral immunity by encoding longnoncoding RNA-155 and microRNA-155-5p. mBio. 2022, e0251022.

3. Yun Ma#, Guijie Guo#, Tingting Li, Faxin Wen, Jianling Yang,Biao Chen, Xuefei Wang and Ji‑Long Chen*. A novel imatinib-upregulated long noncoding RNA plays acritical role in inhibition of tumor growth induced by Abl oncogenes. Molecular Cancer. 2022, 21(1):5.

4. Yingying Li, Shasha Liu, Yuhai Chen, Biao Chen, Meng Xiao, Bincai Yang, Kul Raj Rai,Mohamed Maarouf, Guijie Guo* and Ji-Long Chen*. Syk facilitates influenza A virus replication by restraining innate immunityat the late stage of viral infection. Journal of Virology. 2022; doi:10.1128/jvi.00200-22.

5. Shasha Liu Yuan Liao, Biao Chen, Yuhai Chen, Ziding Yu, Haitao Wei, Lianfeng Zhang, Shile Huang, Paul B. Rothman, George Fu Gao and Ji-Long Chen*. Critical role of Syk-dependent STAT1 activation ininnate antiviral immunity. Cell Reports, 2021,34(3):108627. doi:10.1016/j.celrep.2020.108627.

6. Meng Xiao, Yuhai Chen, Song Wang, Shasha Liu,Kul Raj Rai, Biao Chen, Fang Li, Yingying Li, Mohamed Maarouf and Ji-Long Chen*. Long Noncoding RNAIFITM4P regulates host antiviral responses by acting as a ceRNA. Journal of Virology, 2021, doi: 10.1128/JVI.00277-21.

7. Qingsen Wang, Wenliang Pan, Song Wang, Chen Pan, Hongya Ning, Shile Huang, Shih-Hsin Chiu* and Ji-Long Chen*. Protein tyrosine phosphatase SHP2 suppresses host innate immunity againstinfluenza A virus through regulating EGFR-mediated signaling. Journal of Virology, 2021,95(6):e02001-20.

8. Biao Chen, Yuhai Chen, Kul Raj Rai, Xuefei Wang,Shasha Liu, Yingying Li, Meng Xiao, Yun Ma, Guoqing Wang, Guijie Guo, Shile Huang and Ji-Long Chen*. Deficiencyof eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity. Frontiers in Immunology. 2021;12:723885. doi: 10.3389/fimmu.2021.723885.

9. Kul Raj Rai, Biao Chen, Zhonghui Zhao, YuhaiChen, Jiayue Hu, Shasha Liu, Mohamed Maarouf, Yingying Li, Meng Xiao, Yuan Liao and Ji-Long Chen*. Robustexpression of p27Kip1 induced by viral infection is critical for antiviralinnate immunity. Cellular Microbiology. 2020, e13242.

10. Jiayue Hu, George Fu Gao and Ji-Long Chen*. Strengthening the role of ethnic minority women in science and medicineinChina. Lancet, 2019;393(10171):527-528.

11. Ye Chen, Jin Tian and Ji-Long Chen*. Challenges to eliminaterabies virus infection inChina by 2020. The Lancet Infectious Diseases, 2017,17(2): 135-136.

12. Fang Li, Yuhai Chen, Zhaoyuan Zhang, Jing Ouyang, Yi Wang, Ruoxiang Yan, Shile Huang, George Fu Gao, Guijie Guo and Ji-Long Chen*. Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity. Nucleic Acids Research, 2015; 43(21):10321-37.

13. Jing Ouyang, Xiaomei Zhu, Yuhai Chen, Haitao Wei, Qinghuang Chen, Xiaojuan Chi, Baomin Qi, Lianfeng Zhang, Yi Zhao, George Fu Gao, Guoshun Wang and Ji-Long Chen*. NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription. Cell Host & Microbe, 2014; 16(5):616-626.

14. Haitao Wei, Song Wang, Qinghuang Chen, Yuhai Chen, Xiaojuan Chi, Lianfeng Zhang, Shile Huang, George Fu Gao and Ji-Long Chen*. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLoS Pathogens, 2014; 10(1):e1003845.

15. Song Wang, Xiaojuan Chi, Haitao Wei, Yuhai Chen, Zhilong Chen, Shile Huang and Ji-Long Chen*. Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to the viral replication by suppressing IFITM3 protein expression. Journal of Virology, 2014; 88(15):8375-8385.

16.Jianling Yang, Jun Wang, Ke Chen, Guijie Guo, Ruijiao Xi, Paul B. Rothman, Douglas Whitten, Lianfeng Zhang, Shile Huang and Ji-Long Chen*. eIF4B Phosphorylation by Pim Kinases Plays a Critical Role in Cellular Transformation by Abl Oncogenes. Cancer Research, 2013; 73(15): 4898-4908.

17.Song Wang, Hua Li, Yuhai Chen, Haitao Wei, George F.Gao. , Hongqiang Liu, Shile Huang and Ji-Long Chen*. Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42. The Journal of Biological Chemistry, 2012, 287 (13): 9804-9816.

18. Guijie Guo, Qingzheng Kang, Xiaomei Zhu, Qinghuang Chen, Xuefei Wang, Yuhai Chen, Jing Ouyang, Lianfeng Zhang, Huo Tan, Runsheng Chen,Shile Huang and Ji-Long Chen*. A long noncoding RNA critically regulates Bcr-Abl-mediatedcellular transformation by acting as a competitive endogenous RNA. Oncogene, 2015;34(14):1768-1779.

19.Ji-Long Chen, Andre Limnander and Paul B. Rothman. Pim-1 and Pim-2 kinases are required for Pre-B cell transformation by v-Abl oncogene. Blood, 2008,111(3):1677-1685.

20. Guijie Guo, Xiaoxue Qiu, Song Wang, Yuhai Chen, Paul B. Rothman, Zixu Wang, Yaoxing Chen, Guoshun Wang and Ji-Long Chen*. The oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B cell transformation and survival of Pim-deficient cells. Oncogene, 29, 3845–3853, 2010.

21.Xuefei Wang, Shile Huang and Ji-Long Chen*. Understanding of leukemic stem cells and their clinical implications. Molecular Cancer, 2017; 16(1):2.

22. Xuefei Wang, Jianling Yang, Guijie Guo, Riyue Feng, Ke Chen, Yuan Liao, Lianfeng Zhang, Liping Sun, Shile Huang and Ji-Long Chen*. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway. Molecular Cancer, 2019,18(1):84-95.

23. Song Wang, Lanlan Zhang, Rong Zhang, Xiaojuan Chi, Zhou Yang, Yanhui Xie, Sicheng Shu, Yuan Liao and Ji-Long Chen*. Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function. Veterinary Research, 2018,49(1):98.

24. Yuhai Chen, Jing Ouyang, Ruoxiang Yan, Mohamed Hassan Maarouf, Xuefei Wang, Biao Chen, Shasha Liu, Jiayue Hu, Guijie Guo, Jing Zhang, Sheng-Ming Dai, Huji Xu and Ji-Long Chen*. Silencing SOCS3 Markedly Deteriorates Spondyloarthritis in Mice Induced by Minicircle DNA Expressing IL23. Frontiers in Immunology. 2018 Nov 14;9:2641. doi: 10.3389/fimmu.2018.02641. eCollection 2018.

25. Riyue Feng, Xuefei Wang, Ke Chen, Guijie Guo, Yuan Liao, Liping Sun, Shile Huang and Ji-Long Chen*. Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis. Neoplasia, 2018,20(11):1095-1105.

26. Xiaoyong Chen, Shasha Liu, Mohamed Maarouf, Shile Huang and Ji-Long Chen*. Host immune response to influenza A virus infection. Frontiers in Immunology. 2018; 9:320.

27. Shi-long Chen, Guifeng Luo, Zhou Yang, Shuncheng Lin, Shaoying Chen, Song Wang, Mohsan Ulah Goraya, Xiaojuan Chi, Xiancheng Zeng and Ji-Long Chen*. Avian Tembusu virus infection effectively triggers host innate immune response through MDA5 and TLR3-dependent signaling pathways. Veterinary Research, 2016; 47(1):74.

28. Jingyun Wei, Yanmei Ma, Long Wang, Xiaojuan Chi, Ruoxiang Yan, Song Wang, Xinxin Li, Xiaoyong Chen, Wenhan Shao and Ji-Long Chen*. Alpha/beta interferon receptor deficiency in mice significantly enhances susceptibility of the animals to pseudorabies virus infection. Veterinary Microbiology. 2017; 203:234-244.

29. Binxiang Cai, Qingling Bai, Xiaojuan Chi, Mohsan Ullah Goraya, Long Wang, Song Wang, Biao Chen and Ji-Long Chen*. Infection with classical swine fever virus induces expression of type III interferons and activates innate immune signaling. Frontiers in Microbiology, 2017;8:2558.

30. Song Wang, Chao Chen, Zhou Yang, Xiaojuan Chi, Jing Zhang and Ji-Long Chen*. Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome. Scientific Reports, 2016；6:23746.

31. Song Wang, Xiaoqin Luo, Ruoxiang Yan, Quanxin Wang, Qiuyue Qi, Xiaojuan Chi, Lanlan Zhang, Ziding Yu ,Binxiang Cai, Ji-Long Chen* and Hongwei Liu*. 3-anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. Protein & cell, 2016; 7(11):839-843.

32. Zhilong Chen, Guifeng Luo, Quanxi Wang*, Song Wang*, Xiaojuan Chi, Yifan Huang, Haitao Wei, Baocheng Wu, Shile Huang and Ji-Long Chen*. Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons. Veterinary Microbiology, 2015; 175(2-4):232-243.

33. Mohsan Ullah Goraya, Song Wang, Muhammad Munir and Ji-Long Chen*. Induction of innate immunity and its perturbation by influenza viruses. Protein & Cell, 2015;6(10):712-721.

34. Qinghuang Chen, Ke Chen, GuijieGuo, Fang Li, Chao Chen, Song Wang, Grzegorz Nalepa, Shile Huang and Ji-Long Chen*. A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis. PLoS One, 2014;9(10):e111611.

35. Guijie Guo, Qingzheng Kang, Qinghuang Chen, Zhilong Chen, Jun Wang, Li Tan and Ji-Long Chen*. High expression of long noncoding RNA H19 is required for efficient tumorigenesis induced byBcr-Abloncogene. FEBS Letters, 2014; 588(9):1780-1786.

36. Jing Ouyang, Jiayue Hu and Ji-long Chen*. lncRNAs regulate the innate immune response to viralinfection. Wiley Interdisciplinary Reviews-RNA, 2016, 7(1):129-143.

37. Ji-Long Chen, Raymond V.Fucini, Lynne Lacomis, Hediye Erdjument-Bromage, Paul Tempst and Mark Stamnes*. Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles. Journal of Cell Biology, 2005, 169(3):383-389.

38. Ji-Long Chen, Kathryn L.Huisinga, Michaela M. Viering, Sharon A. Ou, C.-ting Wu and Pamela K. Geyer*. Enhancer action in trans is permitted throughout the Drosophila genome. Proceedings of The National Academy of Sciences of The United States of America, 2002, 99(6):3723-3728.

39. Ji-Long Chen, Jatinder P.Ahluwalia and Mark Stamnes*. Selective effects of calcium chelators on anterogradeand retrograde protein transport in the cell. Journal of Biological Chemistry, 2002,277(38):35682-7.