人物经历
1988年毕业于
南京大学生物化学系，获学士学位;2002年毕业于
澳大利亚墨尔本La Trobe大学生物化学系，获博士学位并于皇家墨尔本医院骨髓研究所进行博士后工作。2006年受聘于
南京大学生命科学院，主要从事基因转录与表观遗传学调控机理研究。
研究方向
1.基因转录调控
2.癌症的发生机理与防治研究
获奖情况
教育部新世纪优秀人才支持计划江苏省“333高层次人才培养工程”第二层次培养对象
江苏省科学技术进步二等奖(1999, No. 2-54-02)
科研成果
1. Wang Y, Wang Y, Ma L, Nie M, Ju J, Liu M, Deng Y, Yao B, Gui T, Li X, Guo C, Ma C, Tan R, Zhao Q*.(2017) Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression. J Biol Chem. 292(12):4811-4817. IF=4.125(* Corresponding author)
2. Chen D, Zuo Y, Zhang X, Ye Y, Bao X, Huang H, Tepakhan W, Wang L, Ju J, Chen G, Zheng M, Liu D, Huang S, Zong L, Li C, Chen Y, Zheng C, Shi L, Zhao Q, Wu Q, Fucharoen S, Zhao C, Xu X.(2017)A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression. Am J Hum Genet. 101(1):130-138. IF=9.025
3.Wang Y, Rank G, Li Z, Wang Y, Ju J, Nuber A, Wu Y, Liu M, Nie M, Huang F, Cerruti L, Ma C, Tan R, Schotta G, Jane SM, Zeng CK, Zhao Q*.(2016) Epsilon-globin expression is regulated by SUV4-20h1. Haematologica.101(5):e168-72. IF=5.814
4.Liu M, Huang F, Zhang D, Ju J, Wu XB, Wang Y, Wang Y, Wu Y, Nie M, Li Z, Ma C, Chen X, Zhou JY, Tan R, Yang BL, Zen K, Zhang CY, Chen YG, Zhao Q*.(2015) Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a. Cancer Res. 75(21):4593-6041. IF=9.329
5.Wu Y, Liu M, Li Z, Wu XB, Wang Y, Wang Y, Nie M, Huang F, Ju J, Ma C, Tan R, Zen K, Zhang CY, Fu K, Chen YG, Wang MR, Zhao Q*.(2015) LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression. Oncotarget. 6(32):32890-32901. IF=6.359
6.Sun Y, Bell JL, Carter D, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Hüttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T.(2015) WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma. Cancer Res.75(23):5143-54. IF=9.329
7.Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L, Zou F, Ma C, Fang M, Tan R, Jane SM, Zhao Q*.(2014) Human fetal globin gene expression is regulated by LYAR. Nucleic Acids Res.42(15):9740-52. IF=9.112
8.He Y, Rank G, Zhang M, Ju J, Liu R, Xu Z, Brown F, Cerruti L, Ma C, Tan R, Jane SM, Zhao Q*. (2013) Induction of human fetal hemoglobin expression by adenosine-2’,3’-dialdehyde. J Transl Med.11(1):14. IF=3.47
9.Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, Simpson R, Moritz R, Jane S, Zhao Q*. (2012) The role of WDR5 in silencing human fetal globin gene expression. Haematologica 97(11), 1632-40. IF=5.814
10.Xu Z, Gao X, He Y, Ju J, Zhang M, Liu R, Wu Y, Ma C, Ma C, Lin Z, Huang X, Zhao Q*.(2012) Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression. Plos One 7(4):e34327. IF= 4.411
11.Rank G, Cerruti L, Moritz RL, Simpson RJ, Jane SM, Zhao Q*.(2010) Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood 116(9): 1585-92. IF=10.558
12.Zhao Q*, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM. (2009) PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol.16(3):304-11. IF=13.685
13.Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM.(2011)Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis. Cancer Cell. 20(5):635-48. IF=26.925
14.Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM.(2010) Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell. 19(1):138-47. IF=13.946
15.Zhao Q, Zhou WL, Rank G, Sutton R, Wang X, Cumming H, Cerruti L, Cunningham JM, and Jane SM. (2006). Repression of human {gamma}-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood. 107 (5):2138-45. IF=10.558
16.McCormack MP, Hall MA, Schoenwaelder SM, Zhao Q, Ellis S, Prentice JA, Clarke AJ, Slater NJ, SalmonJM, Jackson SP, Jane SM, and Curtis DJ.(2006).A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood. 108(7):2248-56. IF=10.558
17.Bosè F, Fugazza C, Casalgrandi M, Capelli A, Cunningham JM, Zhao Q, Jane SM, Ottolenghi S, and Ronchi A.(2006).Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters. Mol Cell Biol, 26(10): 3942-3954. IF=6.188
18.Zhao Q, Cumming H, Cerruti L, Cunningham JM, Jane SM.(2004).Site-specific Acetylation of the Fetal Globin Activator NF-E4 Prevents Its Ubiquitination and Regulates Its Interaction with the Histone Deacetylase, HDAC1. J Biol Chem. 279(40):41477-86. IF=5.328
19.Zhao Q#, Zhou W#, Sutton R, Cumming H, Wang X, Cerruti L, Hall M, Wu R, Cunningham JM, Jane SM. (2004).The role of p22 NF-E4 in human globin gene switching. J Biol Chem. 279(25):26227-32. (#denotes equal contribution) IF=5.328
20.Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ.(2002).A mitochondrial specific stress response in mammalian cells. EMBO J. 21(17):4411-9. IF=10.124