沈萍萍,女,博士学历,
南京大学生命科学学院教授,
博士生导师,教育部跨世纪优秀人才培养计划入选者。
学术兼职
中国免疫学学会理事,
自由基生物学与医学学会理事,中国检测监测联盟理事,
江苏省细胞与发育生物学学会理事,江苏省分子医学生物技术重点实验室学术委员会委员,教育部教学指导委员会委员;Biochemical Pharmacology等SCI杂志编委;
Nature Communication,Sci signaling, Sci rep,J Mol Med、Free radical Bio. Med、Antioxid Redox Sign等SCI刊物审稿人。
研究方向
1. 炎症及肿瘤微环境免疫调控
获奖情况
教学奖励
1.2013年江苏省教学成果奖(高等教育类)一等奖(主要完成人)
2.2007年南京大学优秀教学成果奖(第一完成人)
3.2011年指导的博士论文获全国优秀博士论文提名奖
4.2010年江苏省优秀博士学位论文导师
5.2008年江苏省优秀博士学位论文导师
科研奖励
1.2014年以第一完成人获得江苏省科学技术一等奖 “微囊藻毒素多尺度分析技术体系及健康危害作用机制研究”
2.2007-2008年度“one of Elsevier’s TOP 10 Cited Articles” 奖项;
3.2007年获国际
心血管病论坛“有影响的心血管论文奖”奖项;
4.2006年入选2006年教育部新世纪优秀创新人才计划
5.2006年获第12届世界肿瘤学进展大会“杰出成就奖”(Outstanding Achievement Award, 12th World Congress on Advances in Oncology)。
科研成果
论文
Selected publications:
Niu Z.Y., Shi Q., Zhang W.L., Chen B., Wang Q.S., Zhao X.Y., Chen J.J., Shu Y.X., Cheng N., Feng X.J., Ji J.G., Shen P.P.*, Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs. Nature Communications, 2017, 8(1): 766,
Su Y.Y., Hu M., Fan C.H., He Y., Li Q.N., Li W.X., Wang L.H., Shen P.P.*, Huang Q.*, The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties. Biomaterials , 2010, 31: p. 4829-4834.
Su Y.Y., He Y., Lu H.T., Sai L., Li Q.N., Li W.X., Wang L.H., Shen P.P.*, Huang Q., Fan C.H. *,The cytotoxicity of cadmium based, aqueous phase Synthesized, quantum dots and its modulation by surface coatin. Biomaterials, 2009, 30: p. 19-25.
Liu P., Li C., Zhang R.X., Tang Q., Wei J., Lu Y., Shen P.P. *, An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy. Biosensors and Bioelectronics, 2019,126: p.543-550.
Lin X.Z., Zheng W., Liu J., Zhang Y., Qin H.H., Wu H.C., Xue B., Lu Y., Shen P.P. *, Oxidative stress in malignant melanoma enhances TNF-α secretion of tumor-associated macrophages that promote cancer cell invasion. Antioxidants & Redox Signaling, 2013, 19(12): p.1337-1355.
Lu Y., Zhang Y., Li L., Feng X.J., Ding S., Zheng W., Li J.X., Shen P.P.*, TAB1: a target of triptolide in macrophages. Chemistry & Biology, 2014, 21(2): p.246-256.
Xu H.W., Wei Y.N., Zhang Y., Xu Y.C., Li F., Liu J., Zhang W., Han X.D., Tan R.X., Shen P.P.*, Oestrogen attenuates tumor malignancy in hepatocellular carcinoma progression. Journal of Pathology , 2012, 228: p.216–229 .
Feng X.J., Weng D., Zhou F.F., Young D. Owen, Qin H.H., Zhao J.F., Yu W., Huang Y.H., Chen J.J., Fu H.J., Yang N.F., Chen D.H., Li J.X., Tan R.X., Shen P.P.* , Activation of PPARγ by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization. EbioMedicine, 2016, 9: p.61–76.
Dai H.R. , Zhang W.Y., Li X.L., Han Q.W., Guo Y.L., Zhang Y.J., Wang Y., Wang C.M., Shi F.X., Zhang Y., Chen M.X., Feng K.C., Wang Q.S., Zhu H.L., Fu X.B., Li S.X., Han W.D.*, Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. Oncoimmunology, 2015, 4(11):e1027469.
Sun T.Z., Li X.D., Shen P.P.*, Modeling amplified p53 responses under DNA-PK inhibition in DNA damage response. Oncotarget, 2017, 8(10): p.17105-17114.
Shu Y.X., Lu Y., Pang X.J., Zheng W., Huang Y.H., Li J.H., Ji J.G., Zhang C., Shen P.P.*, Phosphorylation of PPARγ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4. Oncotarget, 2016, 7(47): p.76984-76994.
Feng X.J., Yu W., Li X.D., Zhou F.F., Zhang W.L., Shen Q., Li J.X., Zhang C., Shen P.P.*, Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. Biochemical Pharmacology, 2017, 136: p. 136-149.
Ding S., Qian Steven Y., Zhang Y., Wu W.L., Lu G.S., Lu Y., Feng X.J., Li L., Shen P.P.* Establishment of immunoassay for detecting HPV16 E6 and E7 RNA. Scientific Reports, 2015, 5: p. 13686.
Feng X.J., Sun T.Z., Bei Y.C., Zheng W., Lu Y., Shen P.P.*, S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis. Scientific Reports, 2013, 3: p. 1814.
Niu Z.Y., Tang J.J., Zhang W.L., Chen Y.J., Huang Y.H., Chen B., Li J.H., Shen P.P.*, Caspase-1 promotes monocyte/macrophage differentiation by repressing PPARγ. FEBS Journal, 2017, 284: p. 568–585.
Pang X.J., Wei Y.N., Zhang Y., Zhang M.Y., Lu Y.*, Shen P.P.*, PPARγ activation inhibits hepatocellular carcinoma cell invasion by up-regulating PAI-1. Cancer Science, 2013, 104(6): p. 672-680.
Yao Y.F., Shi Q., Chen B., Wang Q.S., Li X.D., Li L., Huang Y.H., Ji J.G., Shen P.P.*, Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages. Journal of Biological Chemistry, 2016, 291(33): p. 17450-17466.
Yang W.W., Lu Y., Xu Y.C., Xu L.Z., Zheng W., Wu Y.Y., Li L., Shen P.P.*, Estrogen represses Hepatocellular Carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages. Journal of Biological Chemistry, 2012, 287(48): p. 40140-40149.
Dai H.R., Zhou Y., Tong C., Guo Y.L., Shi F.X., Wang Y., Shen P.P.*, Restoration of CD3+CD56+cell level improves skin lesions in severe psoriasis: A pilot clinical study of adoptive immunotherapy for patients with psoriasis using autologous cytokine-induced killer cells. Cytotherapy, 2018, 20: p. 1155-1163.
专利
沈萍萍 ,丰秀静,徐加发,杨威威,一种白杨素噻唑衍生物及其制备方法和应用。2015.08.05,中国,ZL 201310169151.5
沈萍萍 ,丁森,卢彦,一种基于酶联免疫分析的HPV核酸检测试剂盒及其应用。2016.02.23,中国,ZL 201410298037.7
沈萍萍 ,蔡梅红,一种杂合肽囊素佐剂及其制备方法和应用。2014.12.10,中国,ZL 201210295586.X
沈萍萍 ,蔡梅红,一种重组β干扰素的制备方法及其应用。2013.03.13,中国,ZL 201110044022.4
沈萍萍 ,卢彦,徐加法,香豆素标记雷公藤内酯醇及其制备方法和应用。2012.07.25,中国,ZL 200910035979.5
华子春,沈萍萍,潘晓,一种小分子化合物的酵母三杂交检测系统及其在藻毒素检测中的应用。2010.12.01,中国,ZL 200710132796.6
沈萍萍 ,刘培,张瑞旋,一种抗原特异性B细胞筛选方法及其在单克隆抗体制备中的应用,2018.03.06,申请号:201810180889.4
沈萍萍 ,章文龙,唐嘉荩,黄亚红,一种高效的小鼠骨髓来源巨噬细胞的转染方法及其应用,2018.10.17,申请号:201811233196.3
沈萍萍 ,贝云成,黄亚红,一种抑制CDK5协同免疫治疗在抑制乳腺癌中的应用。2018.03.06,申请号:201810180887.5
沈萍萍 ,贝云成,刘培,一种用于乳腺癌免疫治疗的联合用药物组合及其应用。2018.05.14,申请号:201810453420.3
沈萍萍 ,姚永芳,陈兵,黄亚红,一种
间充质干细胞在制备治疗M5型白血病药物中的应用。2016.04 .06,申请号:201610208206.2
沈萍萍 ,牛志远,一种具有抗肿瘤功能的
免疫细胞及其应用。2016.12.02,申请号:201611095758.3
沈萍萍 ,丁森,黄亚红,刘培,一种非扩增型核酸杂交捕获体系及其在核酸检测中的应用。2016.07.20,申请号:201610477993.0
专著
1.参编“植物成分分析”,科学出版社,2003年获选国家教育部优秀研究生教材
2.参编“生物化学原理”,
高等教育出版社出版, 高等教育“十二五国家级规划教材